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Thymocyte-stromal-cell interactions and T-cell selection.

J J Owen·N C Moore
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Abstract

Several key advances have been made since 1992, notably in teh area of signalling in early T-cell development and in the regulation of T-cell selection. Future goals include a fuller understanding of the roles of stromal cells and matrix molecules in T-cell development and further elucidation of the diverse signalling pathways involved. The ultimate challenge will be to generate T cells from stem cells under conditions where all of the developmental cues that earmark thymopoiesis are defined.

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J J Owen, N C Moore. 1995. Thymocyte-stromal-cell interactions and T-cell selection.. https://doi.org/10.1016/0167-5699(95)80150-2

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