PubMed · 7577557
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E Armstrong. Challenging depression.. https://doi.org/10.7748/ns.9.52.55.s54
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The naturalistic course of patients with endogenous subtype of depression is described. The subtype may predict shorter times to remission, and reduced relapse risk. In the longer term, the subtype predicts increased risk of readmission, though studies on recurrence are equivocal. Recurrence of endogenous episodes may be less dependent on life events and personality factors. The subtype does not predict a greater risk of suicide, and most studies show that it does not predict a poorer long-term global outcome. Further prospective studies including operational criteria for course and outcome are needed.
This article reviews studies performed over the last half-century on the lifelong development of risk of recurrence in depressive disorders. It mainly examines the question of the development of the frequency of recurrence, in other words, whether consecutive intervals between depressive episodes lengthen or shorten as episodes continue to recur. Methodological issues have been discussed and recommendations are made for future research.