In-vitro models of B-lineage commitment.

B L Kee; C J Paige

doi:10.1016/1044-5323(95)90042-x

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PubMed · 7579201

In-vitro models of B-lineage commitment.

B L Kee·C J Paige

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Abstract

The development of mature B lymphocytes from multipotent progenitors follows a pathway of differentiation marked by a progressive restriction in lineage options. The requirements for progression through the B lineage developmental pathway have been investigated intensively and a number of critical components of the differentiation process have been identified. However, the genetic basis for lineage determination remains unresolved. Recently, a number of in-vitro assays have been established which support the development of committed B cell progenitors from multipotent cells. These assays have provided a novel system in which the process of B lineage commitment can be followed and manipulated. In this review we present a model of B-lineage progression from multipotent progenitors to committed B-cell progenitors and discuss potential mediators of the commitment process.

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Animals B-Lymphocytes Cell Differentiation Embryonic and Fetal Development Hematopoietic Stem Cells Humans Models, Immunological Journal Article Research Support, Non-U.S. Gov't Review

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B L Kee, C J Paige. 1995. In-vitro models of B-lineage commitment.. https://doi.org/10.1016/1044-5323(95)90042-x

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