Helix design, prediction and stability.

V Muñoz; L Serrano

doi:10.1016/0958-1669(95)80066-2

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PubMed · 7579647

Helix design, prediction and stability.

V Muñoz·L Serrano

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Abstract

Recent work revealing that our knowledge is now sufficient to build a reasonable quantitative model for the helix/coil transition in heteropolypeptides represents a watershed in research into alpha-helix stability, prediction and design. The opportunity is presented to design specific alpha-helix propensity patterns that may be used both to modify thermodynamic properties of target proteins and peptides, and for de novo protein design. Despite these advances, the picture is not yet complete and further studies of still poorly characterized factors are required to obtain a more precise understanding of alpha-helix stability.

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Amino Acid Sequence Models, Molecular Molecular Sequence Data Protein Conformation Protein Engineering Protein Structure, Secondary Proteins Journal Article Review

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V Muñoz, L Serrano. 1995. Helix design, prediction and stability.. https://doi.org/10.1016/0958-1669(95)80066-2

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