Interfacial metal-binding site design.

D J Matthews

doi:10.1016/0958-1669(95)80071-9

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Interfacial metal-binding site design.

D J Matthews

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Abstract

In recent years, much attention has focused on the characterization of metal-binding sites in natural metalloproteins and the design of novel metal-binding motifs. As a result, it is now possible to harness the high specificity and potency of metal-ion binding to modulate intermolecular interactions. Some encouraging results have been obtained using designed metal-binding sites in such diverse applications as the stabilization of artificial peptide assembly, regulation of membrane channels, control of enzyme activity and enhancement of hormone-receptor interactions.

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Binding Sites Chromatography, Affinity DNA-Binding Proteins Enzymes Fungal Proteins Membrane Proteins Metals Protein Engineering Protein Kinases Proteins Saccharomyces cerevisiae Proteins Journal Article Review

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D J Matthews. 1995. Interfacial metal-binding site design.. https://doi.org/10.1016/0958-1669(95)80071-9

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