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PubMed · 7581173

BATO complexes derived from dimethoxy dioximes: synthesis, characterization and biodistribution.

K Ramalingam·S S Jurisson·B L Kuczynski·R Di Rocco·R K Narra·D P Nowotnik·A D Nunn
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Abstract

To prepare less lipophilic BATO complexes, two new methoxy-substituted dioximes were synthesized: cis-4,5-dimethoxycyclohexane-1,2-dione dioxime (DMCDO) and 1,4-dimethoxybutane-2,3-dione dioxime (DMDMG). 99mTcCl(DMCDO)3BMe (BMe = methylboronic acid) was prepared and characterized. Reversed-phase HPLC analyses of 99mTcCl(DMCDO)3BMe and 99mTcCl(DMCDO)3-p-TBA (p-TBA = p - tolylboronic acid) indicated that both of these complexes were mixtures of four enantiomeric pairs of diastereomers. Attempted preparation of a BATO complex from DMDMG gave a mixture of products. In rats, 99mTcCl(DMCDO)3BMe displayed more rapid liver and renal clearance than 99mTcCl(CDO)3BMe, but 99mTcCl(DMCDO)3BMe and 99mTcCl(DMCDO)3-p-TBA displayed low uptake in both heart and brain.

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AnimalsChromatography, High Pressure LiquidGamma CamerasIsotope LabelingMaleOrganotechnetium CompoundsOximesRatsSpectrophotometry, UltravioletStereoisomerismTissue DistributionJournal Article

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K Ramalingam, S S Jurisson, B L Kuczynski, R Di Rocco, R K Narra, D P Nowotnik, A D Nunn. 1995. BATO complexes derived from dimethoxy dioximes: synthesis, characterization and biodistribution.. https://doi.org/10.1016/0969-8051(94)00143-8

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