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PubMed · 7584493

Interleukin-10 and its receptor.

A S Ho·K W Moore
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Abstract

The cytokine interleukin-10 (IL-10) has several important activities on cells of the immune system. IL-10 profoundly suppresses activation of macrophages, inhibiting their ability to secrete cytokines and serve as accessory cells for stimulation of T cell and natural killer (NK) cell function. IL-10 also plays a role in stimulating proliferation and differentiation of B cells, mast cells, and both mature and immature T cells. At least two herpesviruses harbor analogs of the IL-10 gene; the Epstein-Barr virus (EBV) homolog (BCRF1, viral IL-10, vIL-10) shares several of the cellular cytokine's activities, one or all of which may be important in the host-virus relationship. This article reviews recent studies on the function of IL-10 and discusses the initial characterization of its receptor.

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AnimalsAntigen-Presenting CellsAutoimmunityB-LymphocytesCell DifferentiationGenesGenes, ViralHematopoiesisHerpesvirus 4, HumanHumansImmune ToleranceInflammationInterleukin-10Lymphocyte ActivationMacrophage ActivationMacrophagesReceptors, InterleukinReceptors, Interleukin-10T-LymphocytesTh1 CellsTh2 CellsViral Structural ProteinsJournal ArticleReview

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A S Ho, K W Moore. 1994. Interleukin-10 and its receptor.. https://pubmed.ncbi.nlm.nih.gov/7584493/

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