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PubMed · 75852

IgE-induced changes in human basophil cyclic AMP levels.

L M Lichtenstein·A K Sobotka·F J Malveaux·E Gillespie
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Abstract

We studied a unique patient with 77% basophils, not different from normal by a number of criteria, in order to measure the changes in cyclic AMP level associated with IgE-mediated histamine release. In accordance with previous hypothesis and circumstantial evidence, anti-IgE challenge led to a significant fall in the cyclic AMP level which preceded histamine release.

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BasophilsBinding SitesCell MembraneCyclic AMPHistamine ReleaseHumansImmunoglobulin ELeukemia, MyeloidJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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L M Lichtenstein, A K Sobotka, F J Malveaux, E Gillespie. 1978. IgE-induced changes in human basophil cyclic AMP levels.. https://doi.org/10.1159/000232059

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