The number of luteinizing hormone-releasing hormone immunoreactive neurons is significantly decreased in the forebrain of old-aged female rats.

T Funabashi; F Kimura

doi:10.1016/0304-3940(95)11457-8

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The number of luteinizing hormone-releasing hormone immunoreactive neurons is significantly decreased in the forebrain of old-aged female rats.

T Funabashi·F Kimura

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Abstract

To see changes in the number of luteinizing hormone-releasing hormone (LHRH) neurons during aging, young (3 months old)- and old (26 months old)-aged female rats, four of each, were used 4 weeks after ovariectomy for immunocytochemistry. The estimated total number (mean +/- SEM) of LHRH immunoreactive (ir) neurons in the forebrain of old-aged rats (353 +/- 34) was significantly smaller than that in young-aged rats (672 +/- 51). In the forebrain, the decrease in the number of LHRH-ir neurons with age in rostral parts was greater than that in caudal parts, suggesting heterogeneous impairment of LHRH neurons in the rat forebrain during aging.

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Aging Animals Female Gonadotropin-Releasing Hormone Immunohistochemistry Neurons Ovariectomy Preoptic Area Prosencephalon Rats Rats, Wistar Journal Article Research Support, Non-U.S. Gov't

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T Funabashi, F Kimura. 1995-04-14. The number of luteinizing hormone-releasing hormone immunoreactive neurons is significantly decreased in the forebrain of old-aged female rats.. https://doi.org/10.1016/0304-3940(95)11457-8

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