Diabetes affects alpha-crystallin chaperone function.

M Cherian; E C Abraham

doi:10.1006/bbrc.1995.1954

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Diabetes affects alpha-crystallin chaperone function.

M Cherian·E C Abraham

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Abstract

In vitro glycation was previously shown to influence alpha-crystallin chaperone function. In the present study we show that this function is compromised in diabetes. The alpha H, alpha L and the total alpha fractions were isolated by gel permeation chromatography from the water-soluble protein of streptozotocin-diabetic as well as age-matched normal rats. Based on the beta L-crystallin thermal denaturation assay the chaperone function was significantly decreased in the diabetic rats.

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Animals Blood Glucose Chaperonins Chromatography, Gel Crystallins Diabetes Mellitus, Experimental Glycosylation Protein Denaturation Rats Rats, Sprague-Dawley Reference Values Time Factors Journal Article Research Support, U.S. Gov't, P.H.S.

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M Cherian, E C Abraham. 1995-07-06. Diabetes affects alpha-crystallin chaperone function.. https://doi.org/10.1006/bbrc.1995.1954

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