The Escherichia coli RNA polymerase alpha subunit: structure and function.

R H Ebright; S Busby

doi:10.1016/0959-437x(95)80008-5

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The Escherichia coli RNA polymerase alpha subunit: structure and function.

R H Ebright·S Busby

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Abstract

Recent work has established that the Escherichia coli RNA polymerase alpha subunit consists of an amino-terminal domain containing determinants for interaction with the remainder of RNA polymerase, a carboxy-terminal domain containing determinants for interaction with DNA and interaction with transcriptional activator proteins, and a 13-36 amino acid unstructured and/or flexible linker. These findings suggest a simple, integrated model for the mechanism of involvement of alpha in promoter recognition and transcriptional activation.

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Base Sequence DNA, Bacterial DNA-Directed RNA Polymerases Escherichia coli Molecular Sequence Data Protein Conformation Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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R H Ebright, S Busby. 1995. The Escherichia coli RNA polymerase alpha subunit: structure and function.. https://doi.org/10.1016/0959-437x(95)80008-5

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