Alpha/beta interferon is a neuronal growth factor.

A V Plioplys; N Massimini

doi:10.1159/000096838

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Alpha/beta interferon is a neuronal growth factor.

A V Plioplys·N Massimini

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Abstract

We investigated the effect of alpha/beta interferon on neuronal survivability. E16 murine telencephalic vesicles were dissected aseptically and grown on collagen-coated coverslips. After 2 weeks of culturing, the media was supplemented with mouse alpha/beta interferon (1,500 U/ml). After an additional 2 weeks of culturing, all of the control cultures demonstrated significant neuronal death. In the 16 interferon-treated cultures, neuronal death took place only in 1 culture, baseline survivability occurred in 2 and proliferation in 13 cultures (p < 0.005). Thus, alpha/beta interferon sustains neuronal growth.

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Animals Cell Count Cell Division Cell Survival Cells, Cultured Female Interferon-alpha Interferon-beta Mice Nerve Growth Factors Neurons Time Factors Journal Article Research Support, Non-U.S. Gov't

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A V Plioplys, N Massimini. Alpha/beta interferon is a neuronal growth factor.. https://doi.org/10.1159/000096838

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