PubMed · 76155
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J D Anderson, F Eftekhar. 1978-03-18. Laboratory sensitivity or clinical efficacy.. https://doi.org/10.1016/s0140-6736(78)91064-4
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OBJECTIVES: It has been suggested recently that intracellular bacteria surviving antibiotic treatment might serve as a reservoir for recurrent infection. The purpose of this study was to directly examine the location of Escherichia coli bacteria in the mouse bladder after treatment with mecillinam. METHODS: The bladders were studied by use of colony counts, in situ hybridization and electron microscopy. RESULTS: The bacterial counts in the bladder remained approximately 10(3-4) cfu/bladder even after mecillinam treatment had finished, and re-growth in the urine was observed. In the bladder epithelium from treated mice, bacteria cells were occasionally seen, presumably representing intracellularly located bacteria. CONCLUSIONS: This is the first in vivo study indicating that during mecillinam treatment E. coli cells can penetrate the mouse bladder epithelium and persist.