T lymphocytes and aging.

A Globerson

doi:10.1159/000237091

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PubMed · 7620365

T lymphocytes and aging.

A Globerson

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Abstract

Some of the key features of aging effects on T lymphocytes have been illuminated in the last few years from new angles. Experimental evidence indicates a profound increase in the proportion of memory versus naive types of T cells, a decline in the response to activation and in the capacity to enter the cycle, and decline in levels of IL-2, yet an increase in various other cytokines. At least part of these changes are based on altered patterns of T lymphocyte development. Long-term cultures of T cells from young donors show that certain manifestations of aging are acquired under such in vitro conditions. The T lymphocyte compartment thus offers a unique experimental model to investigate different checkpoints in development and function of the cells, as based on vulnerability to the effects of aging.

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Aging Animals Antigens, CD Cell Cycle Cytoskeleton Humans Lymphocyte Activation Major Histocompatibility Complex T-Lymphocytes Viscosity Journal Article Research Support, Non-U.S. Gov't Review

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A Globerson. 1995. T lymphocytes and aging.. https://doi.org/10.1159/000237091

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