A novel phorbol ester from Excoecaria agallocha.

K L Erickson; J A Beutler; J H Cardellina; J B McMahon; D J Newman; M R Boyd

doi:10.1021/np50119a020

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A novel phorbol ester from Excoecaria agallocha.

K L Erickson·J A Beutler·J H Cardellina·J B McMahon·D J Newman·M R Boyd

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Abstract

The novel phorbol ester 12-deoxyphorbol 13-(3E,5E-decadienoate) [1] was isolated as the anti-HIV principle of Excoecaria agallocha leaves and stems collected in northwest Australia. The structure was determined by spectral means. Compound 1 was also a potent displacer of [3H]-phorbol dibutyrate from rat brain membranes.

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Animals Antiviral Agents Chromatography, Liquid HIV-1 Magnetic Resonance Spectroscopy Mass Spectrometry Phorbol Esters Plants, Medicinal Rats Virus Replication Journal Article

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K L Erickson, J A Beutler, J H Cardellina, J B McMahon, D J Newman, M R Boyd. 1995. A novel phorbol ester from Excoecaria agallocha.. https://doi.org/10.1021/np50119a020

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