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Heterogeneous decrease of bone mineral density in the vertebral column of ovariectomized rats.

C García-Moreno·O M Calvo·S Herrero·E Martín·B Suquía·J I San Román·M Martín·J R García-Talavera·J J Calvo·J del Pino
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Abstract

The long-term effect of ovariectomy on the loss of bone mineral density (BMD) was evaluated in rats with and without estrogen treatment; BMD was studied in the lumbar and caudal vertebrae, measured by DXA, to find how the losses of BMD occur in the axial skeleton. Seventy female Wistar rats of 3 months of age were divided into four groups as follows: group 1: control animals; group 2: ovariectomized animals; group 3: ovariectomized animals undergoing treatment with estrogen (0.25 mg/kg per week of 17-beta estradiol); group 4: ovariectomized rats undergoing estrogen treatment only during the last 3 months of the experimental period. No significant differences were found among the groups in regard to the BMD values of the caudal vertebrae at either 3 or 6 months. Likewise, in the lumbar vertebrae there were no significant differences among the groups after 3 months. However, at 6 months, a decrease in the BMDs of the ovariectomized animals with respect to the remaining groups was found: 226 +/- 11 mg/cm2 in the ovariectomized group; 262 +/- 14 mg/cm2 in the controls; 255 +/- 4 mg/cm2 in the rats receiving estrogen treatment for 6 months; and 259 +/- 5 mg/cm2 in the animals receiving estrogen for 3 months. The study also reveals the absence of differences in the bone mineral density between the ovariectomized and control rats when the former received estrogen treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

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Absorptiometry, PhotonAlkaline PhosphataseAnalysis of VarianceAnimalsBody WeightBone DensityBone DevelopmentBone ResorptionCalciumCreatinineDisease Models, AnimalEstradiolEstrogensFemaleHumansHydroxyprolineLumbar VertebraeOsteocalcinOsteoporosis, PostmenopausalOvariectomyRatsRats, WistarSpineTailComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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C García-Moreno, O M Calvo, S Herrero, E Martín, B Suquía, J I San Román, M Martín, J R García-Talavera, J J Calvo, J del Pino. 1995. Heterogeneous decrease of bone mineral density in the vertebral column of ovariectomized rats.. https://doi.org/10.1016/8756-3282(95)00023-7

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