PubMed · 7627879
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L K Clarke. 1995. Restructuring, redesigning, and redirecting our future.. https://pubmed.ncbi.nlm.nih.gov/7627879/
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Advances in understanding of the spectrum of clinical presentations of patients with systemic and cutaneous necrotizing vasculitis as well as further work on pathogenesis of these conditions has helped with diagnosis of these conditions. Therapies for systemic and cutaneous necrotizing vasculitis are based on disease extent, severity, and concomitant conditions in the individual patient. Future multicenter and multidisciplinary studies will provide improved treatments for these challenging clinical situations.
The early stages of genetic therapy present challenges for clinicians and basic scientists. Clinicians must become familiar with new terminology and concepts, and must keep a perspective on the new field in the face of inflated claims and high-profile failures. Basic scientists must continually return to disease models and to patients to determine what are the proper safety issues and relevant efficacy questions for specific diseases and vector systems. And in an era of instant information, all concerned parties must be careful about how progress is communicated to colleagues, patients, and the lay public.