PubMed Health⌕ Search

PubMed · 7634600

Orthopaedic management using new devices and prostheses.

Abstract

The goals of treatment for patients with metastatic disease are control of pain and maintenance of function. Prosthetic arthroplasty is a useful technique for selected indications. Specific indications include (1) reconstruction of large destructive areas that are not amenable to internal fixation, (2) salvage of failed internal fixation devices, and (3) salvage of lesions in which there are no radiotherapy options to prevent disease progression. Custom modular devices allow resection of varying segments of the skeleton. Immediate rigid fixation is achieved with cemented intramedullary stems. Patients are allowed to bear full weight as tolerated immediately postoperatively. A custom modular diaphyseal segmental replacement system allows resection of large diaphyseal lesions and immediate fixation. The complication rate is low after arthroplasty.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

F H Sim, F J Frassica, E Y Chao. 1995. Orthopaedic management using new devices and prostheses.. https://pubmed.ncbi.nlm.nih.gov/7634600/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Hematometrocolpos in an adolescent female treated for pelvic Ewing sarcoma.

Radiation therapy is often used to achieve local control of pelvic Ewing sarcoma in children. The effects of radiation on the female reproductive tract have been well documented in adults with gynecological malignancies, but the long-term consequences of pelvic radiation in pre-pubertal or adolescent girls are not as well described. We report a case of hematometrocolpos developing in an adolescent previously treated with chemotherapy and radiation therapy for pelvic Ewing sarcoma. We describe the clinical presentation, radiographic features, gross pathology, treatment strategies, outcome, as well as putative predisposing factors and preventative interventions.

Bone Neoplasms↗

Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer.

BACKGROUND: Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and mineralized tissues. We determined if KLK4/hK4 expression was associated with, and influenced by, the bone environment of metastatic PCa. METHODS: Immunohistochemistry, in vitro co-culture, cell migration, and attachment assays. RESULTS: hK4 was localized to tumor cells and osteoblasts in bone metastases. KLK4/hK4 increased in LNCaP and PC3 cells co-cultured with SaOs2 cells; SaOs2 KLK4/hK4 was unchanged. Co-culture did not affect cell proliferation but altered alkaline phosphatase activity/mRNA levels in SaOs2 cells. KLK4-transfected PC3 cells had increased migration towards SaOs2 conditioned medium and greater attachment to the bone-matrix proteins, collagens I and IV. CONCLUSIONS: hK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in PCa bone metastasis. Whether this observation is unique to bone metastasis or reflects a role for hK4 in PCa metastasis generally is yet to be established.

Bone Neoplasms↗