Fluticasone propionate for asthma prophylaxis.

doi:10.1136/dtb.1994.32425

PubMed · 7635021

Fluticasone propionate for asthma prophylaxis.

Abstract

Inhaled corticosteroids have an essential role in the management of many patients with asthma, improving control and reducing the need for oral corticosteroids. Used in conventional dosage inhaled corticosteroids are very safe; in high dosage systemic effects are more evident. Fluticasone propionate (Flixotide--Allen & Hanburys), a new inhalation corticosteroid, is promoted as being more potent than conventional preparations (beclomethasone dipropionate and budesonide) and less likely to cause systemic effects. Is this claim justified and what is the place of fluticasone propionate in asthma prophylaxis?

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1994-04-21. Fluticasone propionate for asthma prophylaxis.. https://doi.org/10.1136/dtb.1994.32425

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BACKGROUND AND AIMS: Anorectal pressure studies have demonstrated internal anal sphincter (IAS) hypertonia in patients with chronic anal fissure. It is unknown however, if these changes in IAS function are associated with any abnormality in sphincter morphology. The first aim was to investigate the clinical characteristics and the manometric and endosonographic findings of the IAS in a cohort of patients with chronic anal fissure. The second aim was to investigate the association between these findings and the outcome with topical Glyceryl trinitrate (GTN) therapy. MATERIALS AND METHODS: All patients who presented with chronic anal fissure from November 1999 to May 2004 were included after failure of conservative therapy. Anorectal manometry and anal endosonography were performed before treatment with 0.2% GTN ointment twice daily was initiated. Patients were evaluated after 8 weeks. RESULTS: One hundred and twenty-four patients (66 women, mean age, 45.2 +/- 14.8 years) were included. Hypertonia of the IAS was found in 84 (68%) patients. The mean maximum IAS thickness was 3.6 +/- 0.76 mm (1.6-5.5). An abnormally thick IAS, adjusted by age, was observed in 113 (91.1%) patients. We found no correlation between resting pressure and IAS thickness (r = 0.074; p = 0.41). At 8 weeks, 52 patients (42%) had healed with complete symptoms resolution. No statistically significant differences were observed when clinical features and manometric and endosonographic findings were compared between healing and no-healing fissures. CONCLUSION: The majority of patients with chronic anal fissure present an abnormally thick IAS. Clinical, manometric and endosonographic features had no association with outcome after GTN treatment.

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PubMed2007

Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study.

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