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Effect of piroxicam beta-cyclodextrin complex on experimental inflammation.

C A Amado·S F Taniguchi·L S Sudo·E Kimura·S Oga
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Abstract

1. The effectiveness of the inclusion product of piroxicam with beta-cyclodextrin was compared to that of free piroxicam on inflammatory reactions by using three experimental inflammatory models in rats. 2. The inclusion compound showed anti-inflammatory effects similar to those of simple piroxicam on granuloma tissue formation and arthritis induced by complete Freund adjuvant. 3. In carrageenin-induced pleurisy, the piroxicam beta-cyclodextrin reduced leukocyte mobilization more intensely than non-complexed piroxicam. 4. These results suggest that beta-cyclodextrin is a useful tool for improving the efficacy of piroxicam.

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AnimalsAnti-Inflammatory Agents, Non-SteroidalArthritis, ExperimentalCarrageenanCyclodextrinsFreund's AdjuvantGossypiumGranulomaMalePiroxicamPleurisyRatsRats, Wistarbeta-CyclodextrinsJournal ArticleResearch Support, Non-U.S. Gov't

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C A Amado, S F Taniguchi, L S Sudo, E Kimura, S Oga. 1995. Effect of piroxicam beta-cyclodextrin complex on experimental inflammation.. https://doi.org/10.1016/0306-3623(94)00204-z

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