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PubMed · 7641893

COPII: a membrane coat that forms endoplasmic reticulum-derived vesicles.

C Barlowe
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Abstract

Vesicle budding from the endoplasmic reticulum (ER) has been reconstituted with washed membranes and three soluble proteins: Sec13 complex, Sec23 complex and the small GTPase Sar1p. The proteins that drive this cell-free vesicle budding reaction form an approximately 10 nm thick electron dense coat on ER-derived vesicles. Although the overall mechanism of membrane budding driven by various cytoplasmic coats appears similar, the constituents of this new membrane coat are molecularly distinct from the non-clathrin coat (COP) involved in intra-Golgi transport and the clathrin-containing coats. The new vesicle coat has been termed COPII.

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Biological TransportCOP-Coated VesiclesEndoplasmic ReticulumFungal ProteinsGTP-Binding ProteinsGTPase-Activating ProteinsIntracellular MembranesMembrane ProteinsMonomeric GTP-Binding ProteinsNuclear Pore Complex ProteinsSaccharomyces cerevisiae ProteinsVesicular Transport ProteinsJournal ArticleReview

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BibTeXRIS

C Barlowe. 1995-08-01. COPII: a membrane coat that forms endoplasmic reticulum-derived vesicles.. https://doi.org/10.1016/0014-5793(95)00618-j

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