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PubMed · 7642359

The genetically epilepsy-prone rat (GEPR).

P C Jobe·P K Mishra·L E Adams-Curtis·V U Deoskar·K H Ko·R A Browning·J W Dailey
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Abstract

Two independently inbred strains of genetically epilepsy-prone rats (GEPRs) have been developed. GEPR-3s and GEPR-9s have moderate and severe degrees of seizure predisposition as well as expression, respectively. Seizure predisposition is a fundamental distinction between the normal and epileptic brain. Seizure predisposition in GEPRs and in humans with epilepsy includes spontaneous seizures and exaggerated seizure responsiveness and/or abnormally low thresholds to stimuli which also cause seizures in non-epileptic subjects. Activation of brainstem seizure circuitry by auditory input via the inferior colliculus causes electrographic and behavioral responses in GEPR-9s which replicates human generalized tonic/clonic seizures. Activation of brainstem seizure circuitry by input from forebrain seizure circuitry in GEPRs provides a newly discovered model of complex partial seizures with secondary generalization to tonic/clonic seizures. Thus, seizure predisposition in GEPRs offers a unique opportunity to study the human epilepsies that is not offered in studies of normal brain exposed to convulsant stimuli.

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AnimalsAnticonvulsantsDisease Models, AnimalDisease SusceptibilityDrug Evaluation, PreclinicalElectroencephalographyEpilepsyHumansRatsRats, Sprague-DawleyJournal Article

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P C Jobe, P K Mishra, L E Adams-Curtis, V U Deoskar, K H Ko, R A Browning, J W Dailey. The genetically epilepsy-prone rat (GEPR).. https://doi.org/10.1007/bf02229080

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