[Fibronectin and macrophage].

M Iiyama; Y Shimada; T Kita; H Ito

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PubMed · 7643470

[Fibronectin and macrophage].

M Iiyama·Y Shimada·T Kita·H Ito

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Abstract

Monocyte-macrophages play a great part in atherogenesis. Interaction between macrophages and subendothelial-tissue including basement membrane and intima may play a critical role in atherogenesis. Therefore we examined the ability of macrophages to attach to various types of extracellular matrix proteins, which are the main components of these tissues. Adhesion of macrophages to fibronectin was remarkable compared to collagen. In addition we examined the effect of age on adhesion to fibronectin. Age-related increase in macrophage adhesion to fibronectin was found in vitro. It was also related to the concentration of surface receptors of macrophages which recognize the RGDS sequence within fibronectin (i.e. VLA5) during aging. Age-related increases in macrophage ability to attach to fibronectin may be related to atherogenesis during aging.

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Aging Amino Acid Sequence Animals Extracellular Matrix Proteins Fibronectins In Vitro Techniques Macrophages Male Mice Mice, Inbred C57BL Molecular Sequence Data Oligopeptides Journal Article

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M Iiyama, Y Shimada, T Kita, H Ito. 1995. [Fibronectin and macrophage].. https://pubmed.ncbi.nlm.nih.gov/7643470/

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