Frequency encoding in excitable systems with applications to calcium oscillations.

Y Tang; H G Othmer

doi:10.1073/pnas.92.17.7869

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Frequency encoding in excitable systems with applications to calcium oscillations.

Y Tang·H G Othmer

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Abstract

A number of excitable cell types respond to a constant hormonal stimulus with a periodic oscillation in intracellular calcium. The frequency of oscillation is often proportional to the hormonal stimulus, and one says that the stimulus is frequency encoded. Here we develop a theory of frequency encoding in excitable systems and apply it to intracellular calcium oscillations that results from increases in the intracellular level of inositol 1,4,5-triphosphate.

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Animals Calcium Cytoplasm Inositol 1,4,5-Trisphosphate Kinetics Mathematics Models, Biological Oscillometry Second Messenger Systems Time Factors Journal Article Research Support, U.S. Gov't, P.H.S.

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Y Tang, H G Othmer. 1995-08-15. Frequency encoding in excitable systems with applications to calcium oscillations.. https://doi.org/10.1073/pnas.92.17.7869

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