Asynchronous pituitary adenomas with differing morphology.

E Thodou; G Kontogeorgos; E Horvath; K Kovacs; H S Smyth; S Ezzat

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PubMed · 7646333

Asynchronous pituitary adenomas with differing morphology.

E Thodou·G Kontogeorgos·E Horvath·K Kovacs·H S Smyth·S Ezzat

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Abstract

Recurrent pituitary tumors can sometimes pose a diagnostic and therapeutic challenge. We report a case of a 43-year-old man who presented twice, 13 years apart, with pituitary adenoma marked by headaches, visual impairment, and no signs of endocrinologic abnormality. At initial presentation computed tomographic scan documented a pituitary mass eroding the sellar floor, with suprasellar and parasellar extension. The patient underwent transsphenoidal surgery and the tumor was classified as a silent corticotroph adenoma, subtype 2. Thirteen years later, clinical symptoms of a destructive pituitary mass reappeared. This time, the adenoma revealed typical ultrastructural features of an oncocytoma; it had a different immunocytochemical profile from the first tumor. Given these striking morphologic differences, we consider the two adenomas to represent asynchronous, de novo formations. We conclude that the recurrence of a resected pituitary tumor may also represent a metachronous development of two distinct pituitary adenomas.

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Adenoma Adult Humans Immunohistochemistry Male Microscopy, Electron Multiple Endocrine Neoplasia Neoplasms, Second Primary Pituitary Neoplasms Case Reports Journal Article Research Support, Non-U.S. Gov't

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E Thodou, G Kontogeorgos, E Horvath, K Kovacs, H S Smyth, S Ezzat. 1995. Asynchronous pituitary adenomas with differing morphology.. https://pubmed.ncbi.nlm.nih.gov/7646333/

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