PubMed · 7647221
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J Fareed, J L Francis. 1995. Tissue factor/tissue factor pathway inhibitor.. https://pubmed.ncbi.nlm.nih.gov/7647221/
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Point-of-care testing provides current, accurate information relating to thrombosis and hemostasis in patients. Several forces are driving point-of-care testing, particularly economic factors and improved technology. Point-of-care testing has the potential to improve patient management and to decrease integrated costs, although this remains to be shown. For such testing to be successful, the technology must be complemented by hospital-wide point-of-care testing programs. The role of the laboratorian and pathologist will become important for coordinating programs, maintaining quality assurance, and promoting quality improvement.
von Willebrand factor (vWF) is a complex protein essential to normal haemostasis. It is vital to platelet adhesion in the high shear stress conditions encountered in the small blood vessels. Deficient overall levels of, or the presence of abnormally functioning variants of, vWF lead to the common bleeding disorder termed von Willebrand's disease. Laboratory investigation is aimed at both quantitative and qualitative investigation with a view to classification of the abnormality for each individual patient into a particular sub-type.
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