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PubMed · 7647573

Thyroid hemiagenesis with subacute thyroiditis.

Y Shibutani·D Inoue·H Koshiyama·T Mori
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Abstract

A 58-year-old woman with thyroid hemiagenesis associated with subacute thyroiditis is described. Physical examinations revealed a firm nodule with spontaneous pain and tenderness in the left thyroid lobe. A serum thyroid hormone levels were elevated and thyroid scintiscan with 99mTc pertechnetate showed an extremely low uptake, we made a diagnosis of subacute thyroiditis. A 201Tl thyroid scan demonstrated an enlarged left lobe and absence of the right lobe. Ultrasonography of the thyroid gland revealed an enlarged left lobe occupied mostly with a hypoechoic region. An incidental finding was absence of the right lobe. Two months later thyroid function returned to normal. A follow-up thyroid scintiscan revealed a normal left lobe but absent right lobe. The diagnosis of hemiagenesis was confirmed by CT scan. This appears to be the first case report of thyroid hemiagenesis associated with subacute thyroiditis.

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Blood Cell CountFemaleHumansMiddle AgedRadionuclide ImagingSodium Pertechnetate Tc 99mThallium RadioisotopesThyroid DiseasesThyroid GlandThyroiditis, SubacuteTomography, X-Ray ComputedUltrasonographyCase ReportsJournal Article

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BibTeXRIS

Y Shibutani, D Inoue, H Koshiyama, T Mori. 1995. Thyroid hemiagenesis with subacute thyroiditis.. https://doi.org/10.1089/thy.1995.5.133

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An examination of different Percoll density gradients and magnetic activated cell sorting (MACS) for the enrichment of fetal erythroblasts from maternal blood.

OBJECTIVE: To increase the yield of fetal erythroblasts from the blood of pregnant women by optimising and simplifying the enrichment procedure. METHODS: By using an experimental system whereby cord blood was mixed with normal adult blood, we evaluated the recovery of fetal erythroblasts using different single or double percoll density gradients with or without subsequent enrichment by Magnetic Activated Cell Sorting (MACS). RESULTS: The recovery of erythroblasts on single density gradients increased from 3%-68% of the input erythroblasts with an increase in the density of percoll from 1075 g/l-1098 g/l. Although the use of a double density gradient did eliminate most lymphocytes, it was accompanied by a significant loss of erythroblasts. The combination with MACS enrichment, however, lead to a almost 200 fold increase in the purity of erythroblasts. CONCLUSIONS: Erythroblasts are preferentially retained by higher density gradients. To enhance their purity a subsequent more specific enrichment step, such as MACS is advisable.

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