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PubMed · 7652507

[Progress in adrenoceptor research].

Q D Han
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Abstract

According to pharmacological characteristics and molecular cloning, adrenoceptor is divided into 3 types, and each type contains at least 3 subtypes. The molecular structure of adrenoceptor fits common model of G protein coupled receptors on membrane surface. The structure-function relationship has been basically elucidated by mutation techniques. The ligand binding characteristics are decided by the structures in transmembrane domains, while the G protein coupling sites are in the third intracellular loop. There are extensive crosstalks among the subtypes of adrenoceptor. According to the mechanisms, the crosstalks can be divided into 4 types.

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AnimalsGTP-Binding ProteinsHumansReceptors, AdrenergicEnglish AbstractJournal ArticleReview

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Q D Han. 1995. [Progress in adrenoceptor research].. https://pubmed.ncbi.nlm.nih.gov/7652507/

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