A PC-based graphical simulator for physiological pharmacokinetic models.

D R Wada; D R Stanski; W F Ebling

doi:10.1016/0169-2607(95)01624-3

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A PC-based graphical simulator for physiological pharmacokinetic models.

D R Wada·D R Stanski·W F Ebling

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Abstract

Since many intravenous anesthetic drugs alter blood flows, physiologically-based pharmacokinetic models describing drug disposition may be time-varying. Using the commercially available programming software MATLAB, a platform to simulate time-varying physiological pharmacokinetic models was developed. The platform is based upon a library of pharmacokinetic blocks which mimic physiological structure. The blocks can be linked together flexibly to form models for different drugs. Because of MATLAB's additional numerical capabilities (e.g. non-linear optimization), the platform provides a complete graphical microcomputer-based tool for physiologic pharmacokinetic modeling.

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Anesthetics Animals Computer Graphics Computer Simulation Humans Microcomputers Models, Biological Pharmacokinetics Physiology Software Tissue Distribution Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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D R Wada, D R Stanski, W F Ebling. 1995. A PC-based graphical simulator for physiological pharmacokinetic models.. https://doi.org/10.1016/0169-2607(95)01624-3

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