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PubMed · 7659971

[Sleep and COPD].

E Weitzenblum·A Chaouat·C Charpentier·J Krieger
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Abstract

In COPD patients hypoxaemia does worsen during sleep and particularly during REM sleep. However, severe sleep-related O2 desaturation is only observed in patients who exhibit a marked daytime hypoxaemia. Nocturnal desaturation is due to the combination of alveolar hypoventilation and ventilation-perfusion mismatch; alveolar hypoventilation is the predominant mechanism, at least during REM sleep. Sleep-related hypoxaemia leads to peaks of pulmonary hypertension but also to cardiac arrhythmias. Hypoxaemia can be particularly severe when COPD is associated with a sleep apnoea syndrome (this association is rather frequent). A severe nocturnal desaturation needs a treatment with prolonged oxygen therapy, especially if daytime hypoxaemia (PaO2 < 55-60 mmHg) is present. The real benefit from oxygen therapy limited to sleep time in nocturnal desaturators who have not a significant daytime hypoxaemia, has not been yet demonstrated.

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HumansHypoxiaLung Diseases, ObstructiveSleep, REMJournal ArticleReview

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BibTeXRIS

E Weitzenblum, A Chaouat, C Charpentier, J Krieger. 1995-05-15. [Sleep and COPD].. https://pubmed.ncbi.nlm.nih.gov/7659971/

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