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Nuclear changes in apoptosis.

W C Earnshaw
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Abstract

Specific proteinases of the Ced-3/interleukin-1 beta converting enzyme family trigger a multi-enzyme cascade that drives apoptotic events. Studies with newly developed cell-free systems have begun to identify the substrates of these and other proteinases in apoptosis. Studies with intact cells have revealed that cleavage of the genome into domain-sized fragments precedes the activation of a second nuclease that fragments the DNA into nucleosome-sized pieces.

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AnimalsApoptosisCaenorhabditis elegans ProteinsCaspase 1CaspasesCell NucleusCysteine EndopeptidasesEndopeptidasesEsterasesHelminth ProteinsHumansMitosisJournal ArticleReview

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W C Earnshaw. 1995. Nuclear changes in apoptosis.. https://doi.org/10.1016/0955-0674(95)80088-3

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