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Study on cathepsin B activity in human thyroid tumors.

T Kusunoki·S Nishida·T Nakano·K Funasaka·S Kimoto·K Murata·T Tomura
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Abstract

Cathepsin B activity was measured in human thyroid tissue obtained surgically from 2 patients with Grave's disease, 3 with follicular adenoma, 4 with papillary carcinoma, and 4 with follicular carcinoma. Three normal thyroid tissues were also studied. Comparisons were made between cathepsin B activity and clinical findings, including histopathological diagnosis and the presence or absence of extra-capsular invasion and metastasis. The abilities of original tumors to degrade type I and type IV collagen were also measured. Mean cathepsin B activities of both specimens with benign and those with malignant disease were significantly higher than those of normal thyroid. On cases of thyroid carcinoma, those with extra-capsular invasions and metastasis had the highest cathepsin B activities. Cases with high cathepsin B activities also tended to show high type I and IV collagen degrading abilities. These findings suggest that cathepsin B plays a role in the development of extra-capsular invasion and lymph node metastasis in human thyroid tumors.

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Adenocarcinoma, FollicularAdenomaBiomarkers, TumorCarcinoma, PapillaryCathepsin BCollagenCollagenasesGraves DiseaseHumansLymphatic MetastasisNeoplasm InvasivenessPrognosisThyroid GlandThyroid NeoplasmsJournal Article

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T Kusunoki, S Nishida, T Nakano, K Funasaka, S Kimoto, K Murata, T Tomura. 1995. Study on cathepsin B activity in human thyroid tumors.. https://doi.org/10.1016/s0385-8146(12)80181-7

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