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RNase MRP/RNase P: a structure-function relation conserved in evolution?

R Karwan
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Abstract

RNase P and RNase MRP are related ribonucleoproteins. RNase MRP processes mitochondrial precursor- (primer) RNAs, whereas RNase P cleaves precursor-tRNAs to produce their mature 5'-ends. Both RNase P and RNase MRP are associated with the Th/To ribonucleoprotein suggesting possible interrelated pathways and/or functions. All known RNase P and RNase MRP RNAs contain conserved structural elements possibly involved in catalysis/substrate binding, but these elements do not predict all cellular functions of the RNPs.

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AnimalsBase SequenceBiological EvolutionConserved SequenceEndoribonucleasesHumansMolecular Sequence DataRNARNA, CatalyticRibonuclease PStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

R Karwan. 1993-03-15. RNase MRP/RNase P: a structure-function relation conserved in evolution?. https://doi.org/10.1016/0014-5793(93)80025-p

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