The ups and downs of EAE.

E Heber-Katz

doi:10.3109/08830189309051211

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The ups and downs of EAE.

E Heber-Katz

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Abstract

Experimental allergic encephalomyelitis (EAE) is considered the animal disease model for multiple sclerosis (MS) in humans. However, EAE is an acute disease whereas MS is a chronic disease. The on-off nature in both diseases of autoimmune reactivity suggests a regulatory response by the host, a response which can effect the autoreactive T cell by modulating-up or modulating-down. This review discusses various aspects of this regulation, seen after administration of autoantigen, of antibody directed at the T cell receptor (TcR), and of fragments of the TcR itself.

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Amino Acid Sequence Animals Autoantibodies Autoantigens Down-Regulation Encephalomyelitis, Autoimmune, Experimental Molecular Sequence Data Multiple Sclerosis Myelin Basic Protein Receptors, Antigen, T-Cell, alpha-beta Up-Regulation Journal Article Review

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E Heber-Katz. 1993. The ups and downs of EAE.. https://doi.org/10.3109/08830189309051211

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