Mosaic tile model for tRNA-enzyme recognition.

S V Steinberg; L L Kisselev

doi:10.1093/nar/21.8.1941

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Mosaic tile model for tRNA-enzyme recognition.

S V Steinberg·L L Kisselev

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Abstract

An improved algorithm was elaborated to analyse tRNA interaction with aminoacyl-tRNA synthetase based on analysis of tRNA sequences. The fundamental element defining the interaction between the tRNA and the synthetase is not a single nucleotide but a nucleotide combination named a tile which comprises of a given nucleotide and its neighbours as they are defined by the tertiary structure of the molecule. Informational content of each tile is calculated as its probability to occur exclusively in a set of cognate tRNAs. Based on this algorithm the identity sites of E. coli tRNA(Ala) and tRNA(Gln) were determined. The results are in a good agreement with the biochemical data and provide new information about identity sites of these tRNAs.

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Algorithms Amino Acids Amino Acyl-tRNA Synthetases Escherichia coli Models, Genetic Nucleotides RNA, Bacterial RNA, Transfer RNA, Transfer, Ala RNA, Transfer, Gln Journal Article Research Support, Non-U.S. Gov't

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S V Steinberg, L L Kisselev. 1993-04-25. Mosaic tile model for tRNA-enzyme recognition.. https://doi.org/10.1093/nar%2F21.8.1941

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