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PubMed · 7684961

Sialyltransferase: a novel acute-phase reactant.

J C Jamieson·G McCaffrey·P G Harder
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Abstract

1. Proteins that are released into the circulation in elevated amounts in injured mammals are referred to as acute-phase reactants. Most are liver synthesized glycoproteins of the secretable type. However, Gal-beta(1-->4)-GlcNAc-alpha(2-->6)-sialyltransferase (EC 2.4.99.1) is a novel acute-phase reactant since it is a Golgi membrane-bound enzyme rather than a secretable glycoprotein. 2. The role of glucocorticoids and cytokines in the control of synthesis and expression of acute-phase glycoproteins, including sialyltransferase, is discussed. 3. The acute-phase behaviour of Gal-beta(1-->4)-GlcNAc-alpha(2-->6)-sialyltransferase is dependent on the release of the enzyme from the Golgi in the acute-phase state. The mechanism of release of a catalytically active form of the enzyme is described.

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Acute-Phase ProteinsAnimalsGene ExpressionGolgi ApparatusLiverSialyltransferasesbeta-D-Galactoside alpha 2-6-SialyltransferaseJournal ArticleResearch Support, Non-U.S. Gov'tReview

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J C Jamieson, G McCaffrey, P G Harder. 1993. Sialyltransferase: a novel acute-phase reactant.. https://doi.org/10.1016/0305-0491(93)90165-2

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