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Epitope mapping using bacteriophage peptide libraries.

D P Lane·C W Stephen
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Abstract

Vast libraries of random peptides displayed on the surface of bacteriophage potentially allow identification of specific ligands for any peptide receptor of interest. The sequence specificity of antibody-peptide interactions allows these libraries to be used to define and localize continuous epitopes. Remarkably clear-cut results have been obtained with some antibodies; however, the technique has not proved to be generally applicable.

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Amino Acid SequenceAnimalsAntibodies, MonoclonalAntigen-Antibody ReactionsBacteriophagesCapsidEpitopesHumansMiceMolecular Sequence DataProtein Structure, SecondaryRecombinant Fusion ProteinsTumor Suppressor Protein p53Journal ArticleReview

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D P Lane, C W Stephen. 1993. Epitope mapping using bacteriophage peptide libraries.. https://doi.org/10.1016/0952-7915(93)90016-l

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