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PubMed · 7687074

mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels.

A Butler·S Tsunoda·D P McCobb·A Wei·L Salkoff
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Abstract

Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo-encoded channel resembled "maxi" or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.

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Alternative SplicingAmino Acid SequenceAnimalsCalciumCharybdotoxinDNADrosophilaElectric ConductivityLarge-Conductance Calcium-Activated Potassium ChannelsMembrane ProteinsMiceMolecular Sequence DataOocytesPeptidesPotassiumPotassium ChannelsPotassium Channels, Calcium-ActivatedRNARNA, ComplementaryScorpion VenomsSodiumTetraethylammoniumTetraethylammonium CompoundsTranscription, GeneticXenopusJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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A Butler, S Tsunoda, D P McCobb, A Wei, L Salkoff. 1993-07-09. mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels.. https://doi.org/10.1126/science.7687074

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