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PubMed · 7687987

[The endotoxin receptor CD14].

C Schütt·R Schumann
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Abstract

The knowledge about molecular mechanisms of endotoxin (LPS) recognition by cellular receptor CD14 and its consequences as well as the relationship between soluble and membrane-bound receptor is reviewed. The binding of endotoxins to membrane-bound CD14 is mediated by special so-called LPS-binding serum proteins. The mechanism of signal transduction is not yet known. After activation by LPS, monocytes produce free oxygen radicals, IL-1, IL-6, TNF alpha and other mediators. CD14 is present in normal serum as soluble receptor which can neutralize endotoxins in respect to their monocyte activating capacity.

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Antigens, CDAntigens, Differentiation, MyelomonocyticBacterial InfectionsEndotoxinsGenesGram-Negative BacteriaHumansLipopolysaccharide ReceptorsMonocytesReceptors, Cell SurfaceShock, SepticSignal TransductionJournal ArticleReview

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C Schütt, R Schumann. 1993. [The endotoxin receptor CD14].. https://pubmed.ncbi.nlm.nih.gov/7687987/

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