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Molecules involved in T-cell costimulation.

M K Jenkins·J G Johnson
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Abstract

Maximal expression of the interleukin-2 gene in T cells depends on biochemical signals in addition to those transduced by the T cell antigen receptor. Recent work indicates that the T-cell specific molecule CD28 transduces a 'costimulatory' signal when it binds its ligand, the B7 molecule, on the surface of an antigen-presenting cell. Results from experiments performed during the past year have raised the exciting possibility that immune responses can be either inhibited or augmented by manipulation of the CD28-B7 interaction.

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AnimalsAntigen-Presenting CellsAntigens, CDAntigens, Differentiation, T-LymphocyteAntigens, SurfaceB7-1 AntigenCD28 AntigensCalciumCell DivisionHumansImmune ToleranceInterleukin-2LigandsLymphocyte ActivationMacromolecular SubstancesMiceReceptors, Antigen, T-CellSignal TransductionT-Lymphocyte SubsetsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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M K Jenkins, J G Johnson. 1993. Molecules involved in T-cell costimulation.. https://doi.org/10.1016/0952-7915(93)90054-v

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