[The structural and functional classification and evolution of cytokines].

V P Zav'ialov

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PubMed · 7688623

[The structural and functional classification and evolution of cytokines].

V P Zav'ialov

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Abstract

According to the type of secondary structure, cytokines are classified into three categories: alpha-spiral (IFNs-alpha, beta, omega, gamma; ILS-2, 3,4,5,6,7,9; CSFs-G, M, GM, MGF, PDGF), beta-structural (ILs-1 alpha, beta, TNFs-alpha, beta, FGF) and (alpha + beta)-structural proteins (IL-8, IFN-gamma IP-10, PF-4, bTG, GRO, 9E3). According to the type of tertiary structure, alpha-spiral proteins are grouped into IFN- and IL-2-like families and beta-structural ones into IL-1-, and TNF-like families. Two subfamilies can be identified in the IFN-like family. Theoretical and experimental evidence suggests that the genes IFNs are products of divergent or convergent evolution towards the gene of the ancient intracellular protein alpha-prothymosine, which is evolutionally in turn associated with the L7/I1 protein of two ribosomes. It is suggested that the proteins of the immunoglobulin superfamily, including cytokine receptors descended from the ancient proteins of the unicellular organisms molecular shaperons.

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Amino Acid Sequence Biological Evolution Cytokines Models, Molecular Molecular Sequence Data Protein Structure, Tertiary Receptors, Cell Surface Receptors, Immunologic English Abstract Journal Article Research Support, Non-U.S. Gov't Review

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V P Zav'ialov. 1993. [The structural and functional classification and evolution of cytokines].. https://pubmed.ncbi.nlm.nih.gov/7688623/

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