PubMed Health⌕ Search

PubMed · 7694346

A simple technique for controlled subretinal injections.

Abstract

Recently developed vitrectomy techniques for management of choroidal neovascular membranes and subretinal hemorrhages often involve the subretinal injection of fluid materials. A simple, inexpensive infusion system that allows for the controlled injection of fluid, allowing use of a minimal amount of fluid and maximizing surgeon control, is described.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

R T Wallace, J F Vander. 1993. A simple technique for controlled subretinal injections.. https://doi.org/10.1097/00006982-199313030-00013

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Theoretical estimation of retinal oxygenation during retinal detachment.

The aim of the present work was to simulate the oxygenation of the whole retina during different degrees of retinal detachment. A differential equation describing the oxygenation of the whole retina, at different degrees of detachment, was set up and solved numerically. The results show that the choroid can supply the outer retina with a fairly large amount of oxygen as long as the detachment height is lower than about 1mm. This study thus supports the view that hyperoxia may well prove to be clinically beneficial.

Choroid↗

Contribution of VEGF and PEDF to choroidal angiogenesis: a need for balanced expressions.

Ocular angiogenesis may lead to visual impairment and even irreversible blindness in people of all ages worldwide. Choroidal neovascularization (CNV), a major clinical complication of ocular angiogenesis, is an important cause of vision loss that affects a large number of people. Physiological angiogenesis is tightly controlled by a balance in the expression of angiogenic and anti-angiogenic factors. While the underlying mechanism of CNV is complex, it is attributed to an upset in this balance. The vascular endothelial growth factor (VEGF) is essential in the development of CNV as one of the most potent angiogenic stimulators and vascular permeability factors. Pigment epithelium derived factor (PEDF) is a strong inhibitor of angiogenesis with high neuroprotective effects. VEGF and PEDF both possess multiple biological activities and functions that affect a large variety of tissue cells of the eye and other organs. Inappropriate expression levels are associated with many diseases involving neovascularization. This paper describes the unbalanced expressions of VEGF and PEDF as a cause of CNV. Based on the respective angiogenic and anti-angiogenic properties of VEGF and PEDF, experimental models have been devised to genetically reduce VEGF or enhance PEDF to achieve therapeutic effects. Gene therapy for CNV is promising and is under intensive research.

Choroid↗