Desensitization of angiotensin receptor function.

H Sasamura; V J Dzau; R E Pratt

doi:10.1038/ki.1994.429

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Desensitization of angiotensin receptor function.

H Sasamura·V J Dzau·R E Pratt

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Abstract

Angiotensin II is an eight amino acid peptide which plays a major role in the regulation of cardiovascular homeostasis. The physiologic effects of angiotensin (Ang) II are mediated by a G-protein coupled receptor, termed AT1, which activates phospholipase C. A major factor regulating angiotensin II receptor function is the rapid desensitization following agonist stimulation. However, despite years of investigation, the mechanism by which the angiotensin receptor is regulated remains unclear. The cloning of the AT-1 receptor and the availability of cell lines which stabily express this receptor has helped elucidate these mechanisms. In this paper, we review the data from our laboratory concerning the post-translational regulation of the angiotensin receptor function.

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Animals Cell Line Cloning, Molecular Humans Mice Receptors, Angiotensin Signal Transduction Transfection Journal Article Research Support, U.S. Gov't, P.H.S.Review

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H Sasamura, V J Dzau, R E Pratt. 1994. Desensitization of angiotensin receptor function.. https://doi.org/10.1038/ki.1994.429

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