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Requirement for Lim1 in head-organizer function.

W Shawlot·R R Behringer
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Abstract

Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer.

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AnimalsBase SequenceBiomarkersBrainDNA PrimersEmbryonic InductionEmbryonic and Fetal DevelopmentGene DeletionGene ExpressionGene TargetingGenes, HomeoboxHeadHomeodomain ProteinsLIM-Homeodomain ProteinsMesodermMiceMice, Inbred C57BLMolecular Sequence DataPhenotypeStem CellsTranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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W Shawlot, R R Behringer. 1995-03-30. Requirement for Lim1 in head-organizer function.. https://doi.org/10.1038/374425a0

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