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PubMed · 7702327

Experimental adhesion prophylaxis with recombinant tissue plasminogen activator.

M N Vipond·S A Whawell·D M Scott-Coombes·J N Thompson·H A Dudley
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Abstract

The deposition of fibrin in the peritoneal cavity leads to fibrous adhesion formation. Recombinant tissue plasminogen activator (rtPA), delivered locally, was investigated as a method of preventing adhesion formation. Six standardised areas of peritoneal ischaemia were formed in each of 36 male Wistar rats randomised to three intraperitoneal treatments: (A) no treatment control; (B) carboxymethylcellulose gel; (C) rtPA-carboxymethylcellulose gel combination. At 1 week all animals underwent relaparotomy and the number of ischaemic sites with an adhesion counted by an independent observer. rtPA-treated animals formed fewer adhesions compared with gel alone or controls (median number of adhesions 1.5 versus 2.5 versus 5, P < 0.001, ANOVA). Intraperitoneal rtPA in a slow-release formulation is able to reduce adhesion formation significantly in an animal model and may prove to have clinical benefit.

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Administration, TopicalAnimalsCarboxymethylcellulose SodiumDrug CarriersGelsLaparotomyMalePeritoneal DiseasesRatsRats, WistarRecombinant ProteinsTissue AdhesionsTissue Plasminogen ActivatorJournal Article

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M N Vipond, S A Whawell, D M Scott-Coombes, J N Thompson, H A Dudley. 1994. Experimental adhesion prophylaxis with recombinant tissue plasminogen activator.. https://pubmed.ncbi.nlm.nih.gov/7702327/

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