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Murine B cell development: commitment and progression from multipotential progenitors to mature B lymphocytes.

B L Kee·C J Paige
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Abstract

B lymphocytes, the cellular source of antibody, are critical components of the immune response. They develop from multipotential stem cells, progressively acquiring the traits that allow them to function as mature B lymphocytes. This developmental program is dependent on appropriate interactions with the surrounding environment. These interactions, mediated by cell-cell and cell-matrix interactions, provide the growth and differentiation signals that promote progression along the developmental pathway. This chapter addresses the properties of developing B lineage cells and the nature of the environmental signals that support B lineage progression.

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AnimalsB-LymphocytesBiomarkersCell DifferentiationCellular SenescenceCytokinesGrowth SubstancesHematopoietic Stem CellsMiceJournal ArticleResearch Support, Non-U.S. Gov'tReview

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B L Kee, C J Paige. 1995. Murine B cell development: commitment and progression from multipotential progenitors to mature B lymphocytes.. https://doi.org/10.1016/s0074-7696(08)62158-0

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