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HLA complement gene polymorphisms in multiple sclerosis. A study on 80 Italian patients.

D Franciotta·E Dondi·R Bergamaschi·G Piccolo·G V d'Eril·V Cosi·M Cuccia
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Abstract

We studied C4A, C4B, and Bf complement gene polymorphisms in 80 Italian patients with multiple sclerosis (MS). We observed a significantly higher frequency of C4AQ0 allele in patients with the relapsing-remitting form of MS than in ethnically homogeneous controls. Restriction fragment length polymorphism analysis by Southern blotting of the C4/CYP21 gene complex showed that a structural gene deletion was present in 45% of patients with the C4AQ0 allele. Our data support the hypothesis that relapsing-remitting MS and primarily chronic progressive MS are immunogenetically distinct diseases; further, complement factor abnormalities typical of autoimmune diseases could influence the pathogenesis of MS.

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Case-Control StudiesComplement C4Complement Factor BDNAFemaleGene DeletionHumansItalyMajor Histocompatibility ComplexMaleMultiple SclerosisPolymorphism, Restriction Fragment LengthSteroid 21-HydroxylaseJournal Article

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D Franciotta, E Dondi, R Bergamaschi, G Piccolo, G V d'Eril, V Cosi, M Cuccia. 1995. HLA complement gene polymorphisms in multiple sclerosis. A study on 80 Italian patients.. https://doi.org/10.1007/bf00887817

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