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A random-walk/giant-loop model for interphase chromosomes.

R K Sachs·G van den Engh·B Trask·H Yokota·J E Hearst
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Abstract

Fluorescence in situ hybridization data on distances between defined genomic sequences are used to construct a quantitative model for the overall geometric structure of a human chromosome. We suggest that the large-scale geometry during the G0/G1 part of the cell cycle may consist of flexible chromatin loops, averaging approximately 3 million bp, with a random-walk backbone. A fully explicit, three-parametric polymer model of this random-walk/giant-loop structure can account well for the data. More general models consistent with the data are briefly discussed.

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Base CompositionChromatinChromosomes, HumanHumansIn Situ Hybridization, FluorescenceInterphaseModels, GeneticModels, TheoreticalPolymersRandom AllocationJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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R K Sachs, G van den Engh, B Trask, H Yokota, J E Hearst. 1995-03-28. A random-walk/giant-loop model for interphase chromosomes.. https://doi.org/10.1073/pnas.92.7.2710

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