Parallel signal processing among mammalian MAPKs.

E Cano; L C Mahadevan

doi:10.1016/s0968-0004(00)88978-1

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Parallel signal processing among mammalian MAPKs.

E Cano·L C Mahadevan

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Abstract

The intracellular signalling field is dominated by the mitogen-activated protein kinase (MAPK) cascade and its control, which involves the small GTPase Ras and sequential kinase activation. Until recently, ERK1 and ERK2 were the only cloned and well-characterized mammalian MAPKs; diverse ligand-stimulated, proline-directed protein phosphorylation events were attributed to these kinases. The recent discovery of two other MAPK subtypes, the JNK/SAPK subfamily and p38/RK (mammalian equivalents of HOG1 in yeast), reveals extreme complexity within the family and, most intriguingly, the existence in mammalian cells of parallel MAPK cascades that can be activated simultaneously.

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Amino Acid Sequence Animals Calcium-Calmodulin-Dependent Protein Kinases JNK Mitogen-Activated Protein Kinases Mammals Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Molecular Sequence Data Protein Kinases Protein Serine-Threonine Kinases Protein Synthesis Inhibitors Protein-Tyrosine Kinases Signal Transduction Journal Article Review

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E Cano, L C Mahadevan. 1995. Parallel signal processing among mammalian MAPKs.. https://doi.org/10.1016/s0968-0004(00)88978-1

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