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PubMed · 7717070

Platelet activation by platelet aggregation factor from Eisenia foelide.

R Qian·Y C Zhou·Q Q Zhuang
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Abstract

A platelet activating factor from earthworm, Eisenia foelide (EPAF, 25.9 mumol.L-1), induced human platelet aggregation and 5-HT (maximal release of 89% at EPAF 74.1 mumol.L-1) was detected during this process. Neither creatine phosphate/creatine phosphate kinase (CP/CPK) nor aspirin completely inhibited the EPAF-induced platelet aggregation. In the presence of fibrinogen, EPAF (55.6 mumol.L-1) induced the aggregation of human platelet which had been thrombin-treated and degranulated. Results indicated that EPAF was a potent platelet agonist and the EPAF-induced platelet aggregation was ADP- and TXA2-independent.

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AnimalsBlood Coagulation FactorsBlood PlateletsHumansOligochaetaPlatelet Activating FactorPlatelet AggregationRabbitsRatsSerotoninJournal ArticleResearch Support, Non-U.S. Gov't

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R Qian, Y C Zhou, Q Q Zhuang. 1994. Platelet activation by platelet aggregation factor from Eisenia foelide.. https://pubmed.ncbi.nlm.nih.gov/7717070/

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